1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester
tert-butyl (2-hydroxypropyl)carbamate
CAS: 95656-86-3
Molecular Formula: C8H17NO3
1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester - Names and Identifiers
1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester - Physico-chemical Properties
| Molecular Formula | C8H17NO3 |
| Molar Mass | 175.23 |
| Density | 1.02 |
| Boling Point | 276.4±23.0 °C(Predicted) |
| Flash Point | 120.988°C |
| Vapor Presure | 0.001mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| pKa | 12.42±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4450-1.4490 |
1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester - Introduction
tert-butyl carbamate, commonly known as tert-butyl carbamate, is a chemical compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: colorless transparent liquid
-Molecular formula: C9H19NO3
-Molecular weight: 189.25g/mol
-Melting Point:-46°C
-Boiling Point: 264-266°C
-Density: 0.976g/cm3
-Solubility: Soluble in water and various organic solvents
Use:
- tert-butyl (2-hydroxypropyl)carbamate can be used as a commonly used protecting group compound in organic synthesis.
-It can be used to synthesize biologically active molecules and drugs, and as a drug intermediate.
-This compound can also be used as a substrate for enzyme activators and enzyme inhibitors.
Preparation Method:
The preparation of tert-butyl (2-hydroxypyl) carbamate is usually carried out by the following steps:
1. t-butyl alcohol and dimethylformamide react to obtain dimethyl (t-butoxycarbamate)
2. react dimethyl (t-butoxycarbamate) with potassium bicarbonate to generate ethoxycarbonyl (t-butoxycarbamate) alcohol product
3. Finally, the ethoxycarbonyl (t-butoxycarbamate) alcohol product is reacted with hydroxypropyl amine to give tert-butyl (2-hydroxypropyl)carbamate.
Safety Information:
- tert-butyl (2-hydroxypyl) carbamate needs to be operated under appropriate laboratory conditions, because it may cause fire or explosion in the presence of high temperature, open flame or spark.
-Wear personal protective equipment such as protective gloves, glasses and lab coats to avoid direct contact with skin and eyes.
-When storing, keep it in a cool, dry and well-ventilated place, away from fire and oxidizing agents.
-During handling and use, follow good laboratory practices, such as good ventilation and avoiding inhalation, ingestion or eye penetration. If you come into contact with the compound, rinse immediately with plenty of water and seek medical assistance.
Nature:
-Appearance: colorless transparent liquid
-Molecular formula: C9H19NO3
-Molecular weight: 189.25g/mol
-Melting Point:-46°C
-Boiling Point: 264-266°C
-Density: 0.976g/cm3
-Solubility: Soluble in water and various organic solvents
Use:
- tert-butyl (2-hydroxypropyl)carbamate can be used as a commonly used protecting group compound in organic synthesis.
-It can be used to synthesize biologically active molecules and drugs, and as a drug intermediate.
-This compound can also be used as a substrate for enzyme activators and enzyme inhibitors.
Preparation Method:
The preparation of tert-butyl (2-hydroxypyl) carbamate is usually carried out by the following steps:
1. t-butyl alcohol and dimethylformamide react to obtain dimethyl (t-butoxycarbamate)
2. react dimethyl (t-butoxycarbamate) with potassium bicarbonate to generate ethoxycarbonyl (t-butoxycarbamate) alcohol product
3. Finally, the ethoxycarbonyl (t-butoxycarbamate) alcohol product is reacted with hydroxypropyl amine to give tert-butyl (2-hydroxypropyl)carbamate.
Safety Information:
- tert-butyl (2-hydroxypyl) carbamate needs to be operated under appropriate laboratory conditions, because it may cause fire or explosion in the presence of high temperature, open flame or spark.
-Wear personal protective equipment such as protective gloves, glasses and lab coats to avoid direct contact with skin and eyes.
-When storing, keep it in a cool, dry and well-ventilated place, away from fire and oxidizing agents.
-During handling and use, follow good laboratory practices, such as good ventilation and avoiding inhalation, ingestion or eye penetration. If you come into contact with the compound, rinse immediately with plenty of water and seek medical assistance.
Last Update：2024-04-09 21:00:56
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1-(Boc-amino)-2-propanol1-(tert-Butoxycarbonylamino)-2-propanolN-(2-Hydroxypropyl)carbamic Acid tert-Butyl Ester
1780802-79-0
1780802-79-0